SMAS KRMU Faculty Dr. Md Noushad Javed

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Dr. Md Noushad Javed

Assistant Professor -Medical & Allied Sciences

Interest Area(s)

  • Nanotechnology
  • Nutraceuticals
  • Hydrogels 
  • Lipid nanoparticles
  • Bioavailability 
  • Optimization
I was previously associated with Prof. M. Zahid Ashraf; at the CVS lab in the Department of Biotechnology, Jamia Millia Islamia University, New Delhi, India; as a Postdoctoral; working on novel synthesized polymers based nanoparticles for targeted miRNA delivery and exploring their intervening roles and mechanisms in hypoxia.
 
I have been awarded a Ph.D. in Pharmacy [2013-19] from an Institute of Eminence (IoE) and NIRF (Govt of India) accredited 1st ranked pharmacy institute- School of Pharmaceutical Education & Research at Jamia Hamdard University.  Briefly, in my Ph.D (2013-19) research; entitled “Biopharmaceutical performance of Statin and development of optimized drug delivery using QbD (Quality by Design) approach”; I developed block co-polymer (Poloxamer) stabilized novel mucoadhesive and unique cuboidal shaped bicontinuous carrier system (Limicubes) of Rosuvastatin using an Oleic acid derivative- Monoolein. These rationalized Limicubes exhibited higher ex-vivo penetration, P-gp inhibition, controlled release characteristics, preferred lymphatic absorption, reduce first-pass hepatic metabolism, improved Pharmacokinetic (oral bioavailability) performance, superior pharmacodynamic (hypolipidemic) performances as well as protection towards high cholesterol diet mediated hepato- and neuronal damages. By rationalizing these carriers, we also demonstrated approach to reduce inherent high dose mediated toxicity of loaded drug Rosuvastatin, on Kidney and muscles cells, as evident by serum creatine kinase as well as histopathological assessment.
 
While, I have passed my M.Pharm (Pharmaceutics) from Faculty of Pharmacy, Department of Pharmaceutics, Jamia Hamdard New Delhi. Briefly, in my M.Pharm (Pharmaceutics) [2011-13] major research project, I developed DoE based optimized self-emulsifying system of poorly soluble Curcumin to enhance overall solubility as well as to estimate their radiomodulating impacts against cancer.
 
Additionally, I have completed PG in Statistics, Regulatory Affairs, Process Validation, and Certificate in Unani (Herbal) drugs.
I have published some good papers as a leading (corresponding author) in Seminar in Cancer Biology (Impact Factor:15.7), book chapters in reputed international publishers, and patents (Indian and PCT). I am also serving as an editorial member (guest editor) of CNS & Neurological Disorders - Drug Targets (I.F: 4.388), Current Molecular Pharmacology (I.F: 3.339), and Current drug metabolism (I.F: 3.731).
 
My research skills include integration of judicious and systemic approaches for AI (Artificial intelligence) coupled QbD (Quality by design) mediated synthesis of novel biopolymeric derivatives to develop optimized biomimetic nanomaterials such as Hydrogels, cubosomes, lipid nanoparticles, polymeric nanoparticles, metallic nanoparticles, and nano-hydroxyapatite for inflammatory disorders of the brain, Eyes, cardio-vascular systems, and bones. 
 
In my Ph.D., I integrated QbD approach to preparing optimized cubosme delivery systems of statins, using oleic acid (a key constituent of olive oil) derivative- Monoolein (lipid) which is based on the different statistical tests parameters were found to follow Weibull drug release kinetics. Cubosome enhanced the bioavailability of loaded statins in many folds, along with a significant reduction in high-fat diet mediated inflammation of liver and brain cells, as well as a significant reduction in the extent of statins, mediated rhabdomyolysis (biomarker creatine kinase in skeletal muscles and kidney cells) incidences. 
 
Apart from the synthesis of polymers for the development of different types of drug delivery systems,  in-vitro cell culture, molecular biology techniques, and immunohistochemistry; I also have good expertise in various in-silico approaches which are molecular docking and dynamics, QbD (Quality by Design), DoE (Design of experiments), ANN, 3-D designing for various shapes of solid dosage forms, statistical packages for modeling of in-vitro drug release, IVIVC and PBPK Modelling using PK-sim.
 
Being a good learner, as well as your very diverse and interesting research domains; I strongly believe that in a translational research-driven postdoctoral training position in nanomedicine, where I may be able to judiciously integrate novel therapeutics with nanotechnology-based delivery approaches; would motivate me with a sense of quest as well as professionally trained with new research skills. I anticipate that with my current duties, I would ultimately develop some professional academic excellence attributes and interpersonal leadership qualities, within me. 
 
  • Ph.D: Pharmacy [Pharmaceutics] (2019)  
  • School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi, INDIA.
  • Title: “Biopharmaceutical performance of Statin and development of optimized drug delivery using QbD (Quality by Design) approach”
  • P.G. Dip. Statistics [Software based statistical Ananlysis] (2014)
  • Annamalai University, Chennai, INDIA.
  • M. Pharm. Pharmaceutics (2013) 
  • Department of Pharmaceutics, Jamia Hamdard, New Delhi 110025. INDIA.
  • Project: Development of Curcumin loaded optimized formulation for oral delivery.  
  • B. Pharm: Pharmacy (2011) 
  • Faculty of Pharmacy, Jamia Hamdard, New Delhi 110025. INDIA. 
 
PROFESSIONAL EDUCATION  
  • P.G. Dip. Management (2015):  Annamalai University, Chennai, India 
  • P.G. Dip. Quality Assurance & Regulatory Affairs (2012):  Annamalai University, India 
  • Six Sigma White Belt (2013) Aveta School, USA  
  • Certificate in Intellectual Property Rights (2012): WIPO, Geneva, Switzerland  
  • Certificate in Unani (Traditional medicine) (2011): Jamia Hamdard, New Delhi, India 
 
PROFESSIONAL TRAINING 
  • Molecular Dynamics training (2020), EdGene BioMed, India 
  • 3-D software training for designing and printing (2019), 3-Ding printing solutions, India. 
  • Molecular Docking training (2011) at Bioinformatics Facility, Jamia Hamdard, India. 
  • DFT training AIIMS New Delhi, India
  • GCMS based Metabolomics (2017), BNP Lab Jamia Hamdard, India. 
  • Statistical software training (2014), Annamalai University, India. 
  • Modern Analytical Techniques & regulatory guidelines (2011), Apeejay Satya University, India 
 
  • Research Scholar & Teaching Asst: Jamia Hamdard 2013-2018 
  • Asst Prof.: Apeejay Stya University: 2019
  • Post Doc: JMI- 2019-2021
Process optimization skills 
  • Design of Experiment (DoE), Artificial Neural Network (ANN), QTPPs (Quality targeted Product profile), Risk Estimation Analysis (QRM) and Quality by Design (QbD).   
Nanotechnology  
  • Synthesis of novel polymeric derivatives for polymers or hydrogels-based carriers. 
  • Lipid nanoparticles for targeted delivery. 
  • Green and Microwave synthesis of anti-inflammatory metallic nanoparticles. 
  • Nano-hydroxyapatite for bone regeneration, periodontitis, and drug delivery purposes.           
Instruments handling skills 
  • Ultra-violet spectrophotometer, Fluorescence spectrophotometer, HPLC, DSC, Texture   analyzer, Viscometer; Franz diffusion permeation study, ELISA 
Characterization skills           
  • DLS (Dynamic light scattering), FTIR, Confocal microscopy, X-Ray diffraction, Electron microscopy, HPTLC, GCMS, in-vitro release and stability study, pre-clinical skills 
3-D Software Skills 
  • OpensCAD, Sketch-up-make, Cura and 3D-Scans. 
Pre-clinical skills           
  • Animal dosing, Pharmacokinetic, PBPK modeling, Hypoxia, inflammation and Neuronal disorders, Cell culture, Molecular biology, MTT assay, Western blotting, RT-PCR, Immuno-histochemistry and microbial assay. 
 In-silico (bioinformatics) skills 
  •  Molecular docking, Virtual Screening, DFT and Molecular dynamics. 
Statistical software packages 
  • Excel, Prism, Minitab, SPSS and Matlab 
 
Oral presentation  
  • National seminar on Current Regulations on Herbal Drugs and Food (2017): Jamia Hamdard, New Delhi (India). 
  • Invitee in India International Science Festival (2017): Chennai (India). 
  • 28th Annual conference Indian Society for Atherosclerosis research & international CME: “New Paradigms in Atherosclerosis& Cardio-vascular Disorders” (2015): HIMSAR, New Delhi (India). 
  • 1st India International Science Festival (2015): New Delhi (India). 
  • Invitee in 3rd Annual International Conference MPDDNP (2015): Chitakara University, Punjab (India). 
 Poster presentation  
  • QbD and PAT conference (2016): Jamia Hamdard, New Delhi (India). 
  • India International Science Festival (2016): NPL, New Delhi (India). 
  • National Conf. in Chemistry: Environment & Harmonious Development (2016): Delhi University, India.  
  • Drug Discovery and Development Event (2015): E-seminar 
  • 5th Nanotechnology conference (2015): E-conference 
 Abstract  
  • National seminar on Current Regulations on Herbal Drugs and Food (2017): Jamia Hamdard, New Delhi (India). 
  • QbD and PAT conference (2016): Jamia Hamdard, New Delhi (India).  
  • India International Science Festival (2016): NPL, New Delhi (India). 
  • National Conference in Chemistry: Environment& Harmonious Development (2016): Dept of Chemistry; University of Delhi (India). 
  • NTTAHCS (2015): Integral University, Lucknow (India). 
  • Indian Pharma Convention (2011): DIPSAR, New Delhi (India)
 
RESEARCH GRANTS AND FELLOWSHIP 
  • IsDB Postdoctoral research grant. 
  • International Indo-UK joint research junior research fellowship. 
  • GATE (Life science) research fellowship. 
  • GPAT (Pharmacy) PG fellowship. 
AWARDS 
  • Lord Srinivasan Gold medal, Indian Society for Atherosclerosis research, 2014. 
  • Best scientific poster, The Energy Research Institute (TERI)- India, 2016. 
  • Best oral research, Society of Ethnopharmacology, 2017. 
HONORS 
  • Member, British Society for Nanomedicine (BSNM) 
  • Member, American Association of Pharmaceutical Scientists (AAPS) events. 
  • Member, The International Association for the Exchange of Students for Technical Experience (IAESTE) 
  • Member, Indian Pharmacy Graduates' Association 
  • Member, International Pharmaceutical Forum 
 
SCIENTIFIC ACTIVITIES EDITORIAL MEMBER (THEMATIC ISSUES)  
  • CNS & Neurological Disorders - Drug Targets (I.F: 4.3881) : Ongoing 
  • Current drug metabolism (I.F: 3.731) : 3 Issues completed 
  • Current Molecular Pharmacology (I.F: 3.339) : Ongoing 
  • Editing three books on nanotechnology and neurotherapeutics in Springer, Willey and Apple press.
  • Reviewers of different scientific journals
 
 
Accredited abstract screening committee member of American Association of Pharmaceutical Scientists (AAPS) scientific events.
My project under technology initiative (>0.80 Crores) are under review by DST.
 
Published/Accepted 
  • Pottoo F.H., Javed M.N.*, Rahman J., Abu-Izneid T., Khan F.A. Targeted delivery of miRNA based therapeuticals in the clinical management of Glioblastoma Multiforme. Seminars in Cancer Biology. 2020  . IF: 15.707 
  • Ansari A., Pottoo F.H., Barkat M.A., Harshita, Kamal A., Javed M.N.* Neuroblastoma: modulation of signaling pathways: Therapeutic challenges and opportunities with nanomedicine. Seminars in Cancer Biology. 2019. IF: 15.707 
  • Abu-Izneid T., AlHajri N., Ibrahim A.M., Javed M.N., Salem K.M., Pottoo F.H., Kamal M.A. MicroRNAs in the regulation of immune response against SARS COV-2 and other viral infections. Journal of Advanced Research. 2020.                  F:10.479 
  • Pottoo F.H., Javed M.N., Barkat M.A., Alam M.S., Nowshehri J.A., Alshayban D., Ansari M. Estrogen and serotonin: complexity of interactions and implications for epileptic seizures and epileptogenesis. Current Neuropharmacology. 2018.  IF: 7.363 
  • Alam M.S., Garg A., Saifullah M.K., Tareq A.I., Mohsin M., Manzoor O., Pottoo F.H., Javed M.N.* Gum ghatti mediated, one pot green synthesis of optimized gold nanoparticles: Investigation of processvariables impact using Box-Behnken based statistical design. International Journal of Biological Macromolecules. 2017. IF: 6.953  
  • Pottoo F.H., Tabassum N., Javed M.N., Nigar S., Rasheed R., Khan A., Barkat M.A., Alam M.S., Maqbool A., Ansari M.A., Barreto G.E., Ashraf G.M. The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. 
  • Molecular Neurobiology. 2018  IF: 5.590 
  • Hasnain M.S., Javed M.N., Alam M. S., Rishishwar P., Rishishwar S., Ali S., Nayak A.K., Beg S. Purple Heart plant leaves extract-mediated silver nanoparticles synthesis: Optimization by Box-Behnken design. Materials Science and Engineering: C. 2019.   Last IF: 5.88 
  • Pottoo F.H., Sharma S., Javed M.N., Barkat M. A., Harshita., Alam M.S., Naim M.J., Alam M.U., Azam M.A., Barreto G.E., Ashraf G.M. Lipid-based nanoformulations in the treatment of neurological disorders. Drug Metabolism Reviews. IF: 4.518 
  • Aslam M., Javed M.N.*, Hasan Deeb H., Kaiser Nicola M., Mirza A., Alam M.S., Akhter H., Waziri A. Lipid nanocarriers for neurotherapeuticals: Introduction, challenges, blood-brain barrier and promises of delivery approaches. CNS & Neurological Disorders - Drug Targets. 2021  IF: 4.388 
  • Verma R., Vyas P., Kaur J., Javed M.N., Sarafroz M., Ahmad M., Gilani S., Taleuzzaman M., Approaches for ear-targeted delivery systems in neurosensory disorders to avoid chronic hearing loss mediated neurological diseases. CNS & Neurological Disorders - Drug Targets. 2021   IF: 4.388 
  • Pottoo F.H., Abu-Izneid T., Sudqi A.M., Javed M.N., AlHajri N., Hamrouni A.M. Immune System Response during Viral Infections: Immunomodulators, Cytokine Storm (CS) and Immunotherapeutics in 
  • COVID-19. Saudi Pharmaceutical Journal. 2020.  IF: 4.330 
  • Alam M.S., Javed M.N.*#, Pottoo F.H., Waziri F.H., Almalki F.A., Hasnain M.S., Garg A., Saifullah M.K. QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto-dye. Applied organometallic chemistry. 2019.  IF: 4.105 
  • Javed M.N#., Ashraf G.M., Barreto G.E., Naim M. Current Trends for Rationalizing Brain Targeting 
  • Nanoparticles in Neurological Disorders (Part-I). Current Drug Metabolism. 2020.  IF: 3.731 
  • Javed M.N#., Ashraf G.M., Barreto G.E., Naim M. Trends in Rationalized Brain Targeted Nanoparticles in Neurological Disorders (Part III) Current Drug Metabolism. 2020.  IF: 3.731 
  • Alam M., Javed M.N.*, Imam S.S., Ahmad F.J.,Najmi A.K.,Akhtar M. Thymoquinone lipid nanoparticles cut the Gordian knots of depression via neuroprotective BDNF and downregulation of neuroinflammatory NF-κB, IL-6, and TNF-α in LPS treated rats. Current Drug Metabolism. 2021. IF: 3.731 
  • Aslam M., M.N.*, Deeb H.H., Nicola M.K., Mirza A., Alam M.S., Akhter H., Waziri A., Lipid nanocarriers for neurotherapeuticals: Introduction, challenges, blood-brain barrier and promises of delivery approaches. Drug Metabolism. 2021.                    IF: 3.731 
  • Aslam M., Javed M.N.*#, Deeb H.H., Nicola M.K., Ayisha S.M., Md Saquib, Hasnain M., Alam S., Waziri A. Recent emerging trends in role of lipid based nanoparticles mediated delivery of neurotherapeutical for therapeutical management of neuronal disorders. Current Drug Metabolism. 2020 .   IF: 3.731 
  • Raman S., Mahmood S., Javed M.N., Azmana M., Ahmed K., Al-Japairai S. Current Trends for Rationalizing Brain Targeting Nanoparticles in Neurological Disorders. Current Drug Metabolism. 2020.  IF: 3.731  
  • Javed M.N#., Amin S., Kohli K. Risk assessment integrated QbD approach for development of optimized bicontinuous mucoadhesive Limicubes for oral delivery of Rosuvastatin. AAPS PharmSciTech. 2018  IF: 3.246 
  • Waziri A., Bharti C., Aslam M., Jamil P., Mirza A., Javed M.N., Pottoo U., Ahmadi A., Alam M.S. Probiotics for the Chemoprotective Role Against the Toxic Effect of Cancer Chemotherapy. Anti-cancer Agents in Medicinal Chemistry. 2021.  IF: 2.505 
  • Waziri A., Bharti C., Aslam M., Jamil P., Mirza A., Javed M.N., Pottoo U., Ahmadi A., Alam S., Probiotics for the chemoprotective role against the toxic effect of cancer chemotherapy. Anti-Cancer Agents in Medicinal Chemistry. 2021.  IF: 2.505 
  • Sharma S., Javed M.N., Pottoo F.H., Rabbabi S.A., Barkat M.A., Harshita, Sarfaroz M., Amir M. Bioinspired nanosystems for drug and gene delivery. Pharmaceutical Nanotechnology. 2019.  
  • Sharma S., Javed M.N., Pottoo F.H., Rabbabi S.A., Barkat M.A., Harshita, Sarfaroz M., Amir M. Bioinspired nanosystems for drug and gene delivery. Pharmaceutical Nanotechnology. 2019 
  • Nigar S., Pottoo F.H., Tabassum N., Verma S.K., Javed M.N. Molecular Insights into the Role of inflammation and Oxidative Stress in Epilepsy. Journal of Advances in Medical and Pharmaceutical Sciences. 2016. 
  • Shah A.J., Hassan R., Mohi-ud-din R., Masoodi M., Sabreen S., Wani T.U., Jan R., Javed M.N., Clinical biomarkers and novel drug targets to cut Gordian Knots of Alzheimer's. CNS & Neurological Disorders - Drug Targets  IF: 4.388 
  • 26. Pottoo F.H., Sharma S., Nabi B., Rehman S., Rabbani AS.A., Javed M.N. Blood brain barrier: An overview of challenges and approaches for the treatment of NeuroAIDS and Multiple sclerosis. CNS & 
  • Neurological Disorders - Drug Targets.  IF: 4.388 
 
SELECTED BOOK CHAPTERS 
 
  • Javed M.N*., Alam M.S., Waziri A., Pottoo F.H., Yadav A.K., Hasnain M.S., Almalki F.A. Quality by Design Approach for Development of nanopharmaceuticals. In Pharmaceutical Quality by Design: Principles and Applications. 2020. Elsevier.  
  • Javed M.N., Pottoo F.H., Waziri A., Alam M.S. Polyelectrolyte Complexes of Alginate for Controlling Drug Release. In Alginates in Drug Delivery. 2020. Elsevier.  
  • Javed M.N., Dahiya E.S., Sudqi A.M., Alam M.S. Pottoo F.H. Recent advancement in clinical application of nanotechnological approached targeted delivery of novel delivery herbal drugs. In Nanophytomedicine. 2020. Springer. 
  • Javed M.N*., Alam M.S, Pottoo F.H., Naim M.J., Hasnain M.S. (2020).Design of experiments for the development of nanoparticles, nanomaterials and nanocomposites. In Design of Experiments for Pharmaceutical Product Development. Springer Press. 
  • Pandey M., Saleem S., Javed M.N. Pottoo F.H., Nautiyal H. (2020). Role of perk1/parkin in neurodegenerative diseases. Neurodegenration. IGI global Press. 
  • Bharti C., Alam M.S., Javed M.N., Saifullah K., Almalki F.A., Manchanda R. Silica Based Nanomaterials for drug delivery. In Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery. 2021. Bentham Science. 
  • Kumar A., Walia H., Pottoo F.H., Javed, M. N. Insights of Nanophytomedicines as a Combinatorial Therapy in Disease Diagnosis and Treatment. In Nanophytomedicine. 2020. Springer. 
  • Javed M.N*., Akhter M. H., Taleuzzaman M., Faiyazuddin M., Alam M.S. Cationic polymer-mediated brain-targeted delivery of nutraceuticals via lipid encapsulated bionanomaterials in neuronal disorders. In Fundamentals of BioNanomaterials. 2021. Elsevier. 
  • Akhtar H., Javed M.N. et al., Porphyrin based nanomaterials for cancer nanotherasnostics. In Cancer Nanotheanostics. 2021. Springer 
  • Saha P., Javed M.N. et al., Clinical potential of nanotechnlogy as smart therapeutics:A step towards targeted drug delivery. In Recent Advances in Nanotechnology-based Drug Delivery Systems. 2021. Elsevier. 
  • Taleuzzaman M., Chauhan S., Tomar D.S., Singh P.K., Talwar I., Javed M.N*. Lipid nanoformulation of nutraceuticals as neurotherapeuticals in neurological disorders. In Handbook on Nanotechnology in Functional Foods. 2021. Willey. 
  • Mishra G., Pottoo F. H., Javed M.N., Singh P. Nutraceuticals for Fibromyalgia and Neuropathic Pain. 2021. Igi global. 
  • Kumar R., Dhamija G., Ansari J.R., Javed M.N., Alam M.S. C-dots nanoparticulated devices for biomedical Applications. In Nanotechnology: Device design and application. 2021. Apple Press 
  • Taleuzzamam M., Sartaj A., Javed M.N*., Alam J. Advanced Nanotechnology techniques for manufacturing of Engineered polymeric biomaterials-based nanoparticles for Cancer treatment. In Advanced Manufacturing Techniques for Engineering and Engineered Materials. 2021. Igi global 
  • Mustafa G., Hamdani M., Javed M.N., Anjum V., Pottoo F.H., Bhat Z.A. Nutraceuticals for Neurodevelopmental disorders in bioactive nutraceuticals for Brain disorders. In Bioactive nutraceuticals for brain disorder 2021. Bentham Science. 
  • Singhal S., Guta M., Alam M.S., Javed M.N., Ansari J.R. Carbon allotropes based nanodevices: 
  • Graphene in biomedical applications. In Nanotechnology: Device design and application. 2021. Apple Press 
PATENTS & TECHNOLOGIES DEVELOPED  
  • PCT (International) Patents - WO2017060916A1.  Role: Applicant & Investigator 
  • Indian Patents 2091/DEL/2015. Role: Applicant & Investigator